Cembranoides 2,11-ciclizados del Caribe Mesoamericano: origen, estructura y actividad biológica

O. Cóbar

doi:10.54495/Rev.Cientifica.v19i2.152

Autores/as

O. Cóbar Departamento de Química Orgánica, Escuela de Química, Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos de Guatemala

DOI:

https://doi.org/10.54495/Rev.Cientifica.v19i2.152

Palabras clave:

Cembranoides, metabolite secundario, asbestinino, briarellina, cunicelina, sarcodictina, Briareum, Erithropodium

Resumen

Los cembranoides 2.11-cicüzados son una familia de diterpenoides altamente funcionalizados aislados may oritar i ámente de octocoralcs del mar caribe. Biogenéticamente se proponen como derivados de la ciclacion de la molécula del cembrano, con posteriores ciclaciones oxidativas que originan el esqueleto carbonado de asbestinino, briaicllina, eunicelina y saicodictina. Sesenta y nueve cembranoides 2,11 ciclizados se han aislado hasta diciembre do 2009 de tres gorgonios del caribe mesoamericano, treinta y nueve Asbestininos, veintidós Briarellinas, siete Sarcodictinas y una Eunicelma, dejos cuales cuarenta y cuatro son de Bria retan asbeslinum, dieciocho de Bria retan polyajiíhes y siete de Eritliropodium caribaeorum. Estos metabolites poseen diversidad de actividades biológicas que van desde citotóxicas, antimmorales hasta antibacterianas y anti -inflamatorias.

El número importante de estos metabolites, aunado a su variada y sorprendente actividad biológica y aspectos estructurales únicos, los hacen moléculas que deben ser sujetas a estudios profundos, tanto en su potencial farmacológico, como en el análisis de la relación entre su estructura y actividad biológica.

El origen biosintético/estructura y actividad biológica de estos sesenta y nueve cembranoides se describen en este artículo.

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