Caracterización de carbapenemasas en enterobacterias de muestras de pacientes que acudieron al Hospital General San Juan de Dios de la ciudad de Guatemala durante 2014 y 2015

Etelvina Isabel Guerra Carías; Laura Valenzuela Acevedo; Tamara Velásquez Porta

doi:10.54495/Rev.Cientifica.v29i2.34

Authors

Etelvina Isabel Guerra Carías Químicas y Farmacia, Universidad de San Carlos de Guatemala
Laura Valenzuela Acevedo Área de bacteriología, Hospital General San Juan de Dios de la ciudad de Guatemala
Tamara Velásquez Porta Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos de Guatemala

DOI:

https://doi.org/10.54495/Rev.Cientifica.v29i2.34

Keywords:

Carbapenemases, carbapenemases-producing enterobacteriaceae (CPE), metallo-β-lactamases (MBL), Klebsiella pneumoniae carbapenemase (KPC)

Abstract

In public health worldwide, carbapenemase production is currently the biggest problem of antimicrobial resistance. The objective of this study was to characterize carbapenemases in Enterobacteriaceae of patients who attended the San Juan de Dios General Hospital in Guatemala City and to determine hospital services and types of samples more frequent. Data from 2014 and 2015 of the bacteriology department of the hospital were used; a systematic review, selection, ordering and calculation of frequencies and percentages was conducted. n 2014, 165/165 (100 %) of the carbapenemases were metallo-β-lactamases (MBL); in 2015, 90/118 (76 %) MBL and 28/118 (24 %) Klebsiella pneumoniae carbapenemase (KPC). Klebsiella pneumoniae was the carbapenemases producing Enterobacteriaceae (CPE) most frequently isolated, 134/165 (81%) in 2014 and 82/118 (69%) in 2015. In 2014 the neonatal intensive care unit obtained the highest percentage in CPE, 30/165 (18 %); in 2015, men's medicine was the service with the highest percentage of carbapenemases, 11/138 (11 %). The most frequent type of sample in 2014 was blood, 67/165 (41%). In 2015 it was urine, 31/118 (26%). e results obtained highlight the persistence of MBL-type carbapenemases and the
appearance of new types of carbapenemases, speciﬁcally KPC. These results underline the need to act urgently in Guatemala in the face of the problems that carbapenemases-producing Enterobacteriaceae pose for the health of the population.

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